验证数据展示
产品信息
82874-1-PBS targets UGT8 in Indirect ELISA applications and shows reactivity with Human samples.
| 经测试应用 | Indirect ELISA Application Description |
| 经测试反应性 | Human |
| 免疫原 | UGT8 fusion protein Ag13137 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | UDP glycosyltransferase 8 |
| 别名 | Cerebroside synthase, CGT, UDP glycosyltransferase 8, UGT4, UGT8 |
| 计算分子量 | 541 aa, 61 kDa |
| GenBank蛋白编号 | BC075069 |
| 基因名称 | UGT8 |
| Gene ID (NCBI) | 7368 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q16880 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
UGT8, also known as galacotosylceramide synthase or CGT (ceramide galactosyltransferase), is a key enzyme for galacotosylceramide (GalCer) biosynthesis. It is an ER transmembrane protein and has limited tissue distribution, with predominance in Schwann cells, oligodendrocytes, kidneys, testes, and intestine. UGT8 is highly enriched in myelin in the central nervous system. Its expression levels are strongly associated with histological typing in human oligodendrogliomas and astrocytomas; can be used as molecular marker to distinguish these tumors. Higher UGT8 levels had also been linked to metastatic properties of cancer cells.