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Tulathromycin A

Tulathromycin A (CP 472295) 是一种大环内酯类抗生素，靶向细菌核糖体抑制蛋白质合成 (IC50=0.26 µM)，具有免疫调节作用。它可研究牛和猪的呼吸道疾病。

CAS号

217500-96-4

分子式

C41H79N3O12

主要靶点

Antibiotic|Antibacterial

仅限科研使用

Cat No : CM02918

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Synonyms

Tulathromycin|Draxxin|CP 472295|托拉菌素 A

验证数据展示

  • CAS No.: 217500-96-4

    Tulathromycin A
    CAS#: 217500-96-4

产品信息

Tulathromycin A is a macrolide antibiotic.

CAS号 217500-96-4
分子式 C41H79N3O12
主要靶点 Antibiotic|Antibacterial
主要通路 微生物学
分子量 806.09
纯度 99.46%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Tulathromycin|Draxxin|CP 472295|托拉菌素 A

靶点活性

antibacterial:1 microg/ml (MIC90 for Pasteurella multocida)

体内活性

Each study randomly allocated 250 calves to receive tulathromycin at 2.5 mg/kg and 250 calves to receive either florfenicol at 40 mg/kg or tilmicosin at 10 mg/kg on arrival at the feedlot. Calves were housed by treatment group in pens with 50 calves/pen. The treatment groups were physiologic saline (n=160) given SC at 0.02 ml/kg, tulathromycin (n=20) given SC at 2.5 mg/kg, and tilmicosin (n = 320) given SC at 10 mg/kg.

体外活性

145 calves were inoculated by two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 μg/ml). Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures, and lung lesion scores were significantly lower for tulathromycin-treated calves (P < .01). Tulathromycin was highly effective in the treatment of BRD due to M. bovis in calves regardless of the minimum inhibitory concentration of the challenge strain (1 or >64 μg/ml). The MIC90 for tulathromycin were 1 μg/ml for Pasteurella multocida (bovine), 2 μg/ml for Mannheimia (Pasteurella) haemolytica, and 2 μg/ml for Pasteurella multocida (porcine) and ranged from 4-16 μg/ml for Actinobacillus pleuropneumoniae and from 0.5-4 μg/ml for Histophilus somni (Haemophilus somnus).

溶解度

DMSO:45 mg/mL

参考文献

1.Villarino N, et al. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally withlipopolysaccharide from Escherichia coli. Antimicrob Agents Chemother. 2012 Aug;56(8):4078-4086.
2.Godinho KS, et al. Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves. Vet Ther. 2005 Summer;6(2):96-112.
3.Godinho KS, et al. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology. Vet Ther. 2005 Summer;6(2):113-21.
4.Rooney KA, et al. Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease. Vet Ther. 2005 Summer;6(2):154-66.

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