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Troxerutin

Troxerutin (Trihydroxyethylrutin) 是一种天然生物类黄酮芦丁的三羟乙基化衍生物，也被称为维生素 P4，可抑制活性氧的产生并抑制 ER 应激介导的NOD 活化。

CAS号

7085-55-4

分子式

C33H42O19

主要靶点

NOD-like Receptor (NLR)

仅限科研使用

Cat No : CM04160

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Synonyms

维脑路通|Trihydroxyethylrutin|曲克芦丁

验证数据展示

  • CAS No.: 7085-55-4

    Troxerutin
    CAS#: 7085-55-4

产品信息

Troxerutin, a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties.

CAS号 7085-55-4
分子式 C33H42O19
主要靶点 NOD-like Receptor (NLR)
主要通路 免疫与炎症
分子量 742.67
纯度 95.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 维脑路通|Trihydroxyethylrutin|曲克芦丁

体内活性

Troxerutin可使红细胞聚集减少,并有助于改善毛细血管灌注,郁积和慢性静脉功能不全的营养并发症。 Troxerutin通过减少蛋白羰基,活性氧和糖基化终产物水平,并且增强PI3K/Akt的活化减弱D-半乳糖诱导的氧化应激和认知损害。Troxerutin还能降低急性心肌梗塞患者血浆中的α-氨基己二酸,同型半胱氨酸,甘油三酯,胆固醇,以及低密度脂蛋白载脂蛋白B水平。

溶解度

Ethanol:<1 mg/mL,DMSO:93 mg/mL (125.2 mM),H2O:92 mg/mL (123.9 mM)

参考文献

1.Olszewski AJ, et al. Atherosclerosis, 1989, 75(1), 1-6.
2.Boisseau MR, et al. J Cardiovasc Surg (Torino), 1995, 36(4), 369-374.
3.Lu J, et al. Brain, 2011, 134(Pt 3), 783-797.
4.Zhang Z, et al. Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci. 2016 Dec 25;18(1). pii: E31.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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