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Tirofiban

CAS号

144494-65-5

分子式

C22H36N2O5S

主要靶点

Integrin

仅限科研使用

Cat No : CM04781

Print datasheet

Synonyms

Aggrastat|ACSs|antithrombotic|AMI|GPIIb/IIIa|HUVEC|HAEC|inhibit|Tirofiban|VEGF|替罗非班|Inhibitor|Integrin|L 700462|L700462|L-700462|MK383|MK-383|MK 383

验证数据展示

  • CAS No.: 144494-65-5

    Tirofiban
    CAS#: 144494-65-5

产品信息

CAS号 144494-65-5
分子式 C22H36N2O5S
主要靶点 Integrin
主要通路 细胞骨架
分子量 440.6
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Aggrastat|ACSs|antithrombotic|AMI|GPIIb/IIIa|HUVEC|HAEC|inhibit|Tirofiban|VEGF|替罗非班|Inhibitor|Integrin|L 700462|L700462|L-700462|MK383|MK-383|MK 383

靶点活性

GPIIb/IIIa:9 nM

体内活性

Tirofiban (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. [4] When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. [5][6]

体外活性

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. [1][2] It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μMol/L. [3]

溶解度

DMSO:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Hartman GD, et al. J Med Chem, 1992, 35(24), 4640-4642.
2.Egbertson MS, et al. J Med Chem, 1994, 37(16), 2537-2551.
3.Coller BS, et al. J Clin Invest, 1997, 100(11 Suppl), S57-60.
4.Lynch JJ Jr, et al. J Pharmacol Exp Ther, 1995, 272(1), 20-32.
5.Barrett JS, et al. Clin Pharmacol Ther, 1994, 56(4), 377-388.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2