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Tigogenin

Tigogenin 是甾体皂甙元，普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化，促使成骨细胞的分化。

CAS号

77-60-1

分子式

C27H44O3

主要靶点

Others

仅限科研使用

Cat No : CM06579

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Synonyms

验证数据展示

  • CAS No.: 77-60-1

    Tigogenin
    CAS#: 77-60-1

产品信息

Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.

CAS号 77-60-1
分子式 C27H44O3
主要靶点 Others
主要通路 其他
分子量 416.64
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

Tigogenin enhanced the proliferation of BMSCs significantly.?Tigogenin treatment reduced the adipogenic induction of lipid accumulation, visfatin secretion, and the expressions of peroxisome proliferation-activated receptor (PPAR)gamma2 and adipocyte fatty acid-binding protein (ap)2.?Moreover, tigogenin had no effect on the mitotic clonal expansion.?On the other hand, tigogenin significantly elevated alkaline phosphatase (ALP) activity and the expressions of Cbfa1, collagen type I (COL I) and osteocalcin (OCN), as well as the content of matrix calcium in BMSCs[1].

溶解度

DMSO:Insoluble,H2O:Insoluble

参考文献

1.Zhou H , Yang X , Wang N , et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[J]. Molecular and Cellular Endocrinology, 2007, 270(1-2):17-22.
2.Liagre B , Vergne-Salle P , Leger D , et al. Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2[J]. International Journal of Molecular Medicine, 2007, 20(4):451---460.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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