• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Theaflavin

CAS号

4670-05-7

分子式

C29H24O12

主要靶点

Endogenous Metabolite|Influenza Virus

仅限科研使用

Cat No : CM04157

Print datasheet

Synonyms

EndogenousMetabolite|inhibit|InfluenzaVirus|Influenza A virus|Influenza Virus|Endogenous Metabolite|Theaflavin|茶黄素|Inhibitor

验证数据展示

  • CAS No.: 4670-05-7

    Theaflavin
    CAS#: 4670-05-7

产品信息

CAS号 4670-05-7
分子式 C29H24O12
主要靶点 Endogenous Metabolite|Influenza Virus
主要通路 微生物学|代谢
分子量 564.49
纯度 99.28%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 EndogenousMetabolite|inhibit|InfluenzaVirus|Influenza A virus|Influenza Virus|Endogenous Metabolite|Theaflavin|茶黄素|Inhibitor

体内活性

在预处理的ICH大鼠中，Theaflavin显著缓解了行为缺陷，保护了血脑屏障（BBB）的完整性，减少了脑水肿的形成和活性氧（ROS）以及炎症细胞因子（包括白细胞介素-1β[IL-1β]、IL-18、肿瘤坏死因子-α、干扰素-γ、转化生长因子β和(C-X-C基序)配体1[CXCL1]）的水平。Nissl染色和TUNEL实验显示，Theaflavin通过抑制核转录因子kappa-β-p65（NF-κβ-p65）、caspase-1和IL-1β[2]的激活，保护神经细胞免受损失和凋亡。

体外活性

Theaflavin 抑制OVCAR-3 和 A2780/CP70 人类卵巢癌细胞系的生长，但对卵巢上皮细胞系IOSE 364 不产生抑制作用（IC50 分别为11.9、38.5 和 >40 μM）[1]。

溶解度

DMSO:5.65 mg/mL (10 mM)

细胞实验

Cell proliferation assay, Hoechst 33342 staining assay, Caspase-Glo Assay, western blot, human umbilical vein endothelial cell tube formation assay and vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay were performed[1].

动物实验

ICH rat models were induced with type VII collagenase and pretreated with TF by gavage in different doses (25 mg/kg-100 mg/kg).?Twenty-four hours after ICH attack, evaluated the rats' behavioral performance, the blood-brain barrier (BBB) integrity, and the formation of cerebral edema.?The levels of reactive oxygen species (ROS) and inflammatory cytokines were examined by 2',7'-dichlorofluorescin diacetate and enzyme-linked immunosorbent assay.?Nissl staining and transferase dUTP nick end labeling (TUNEL) were aimed to detect the neuron loss and apoptosis, the mechanism of which was explored by Western blot[2].

参考文献

1.Gao Y , Rankin G O , Youying T U , et al. Inhibitory Effects of the Four Main Theaflavin Derivatives Found in Black Tea on Ovarian Cancer Cells[J]. Anticancer research, 2016, 36(2):643-651.
2.Guanglei F , Hua W , Youli C , et al. Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats[J]. Drug Design, Development and Therapy, 2018, Volume 12:1609-1619.
3.Juarez-Mercado K E, Prieto-Martinez F D, Sanchez-Cruz N, et al. DNA Methyltransferase Inhibitors with Novel Chemical Scaffolds[J]. bioRxiv. 2020
4.Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors[J]. Pharmaceuticals. 2021, 14(1): 17.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2