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(E/Z)-Teriflunomide

(E/Z)-Teriflunomide (Aubagio) 是一种可口服的嘧啶合成抑制剂，用于治疗复发性多发性硬化症。

CAS号

108605-62-5

分子式

C12H9F3N2O2

主要靶点

Dehydrogenase

仅限科研使用

Cat No : CM00396

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Synonyms

特立氟胺|Flucyamide|Aubagio|HMR-1726|A77 1726

验证数据展示

  • CAS No.: 108605-62-5

    (E/Z)-Teriflunomide
    CAS#: 108605-62-5

产品信息

(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.

CAS号 108605-62-5
分子式 C12H9F3N2O2
主要靶点 Dehydrogenase
主要通路 代谢
分子量 270.21
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 特立氟胺|Flucyamide|Aubagio|HMR-1726|A77 1726

体内活性

Teriflunomide是二氢乳清脱氢酶抑制剂,从而抑制快速增殖的细胞中嘧啶的从头合成。Teriflunomide能够抑制具有高度增殖活性的T淋巴细胞和B淋巴细胞,从而降低自身抗原的炎症应答。

体外活性

在脱髓鞘疾病动物模型中,Teriflunomide能够产生作用.比如,自身免疫性脑炎的黑刺鼠模型中,Teriflunomide具有预防和治疗的作用;在EAE的雌性Lewis大鼠模型中,Teriflunomide能够改善疾病症状,缓解疾病的发作.

溶解度

DMSO:27 mg/mL (100 mM)

参考文献

1.Oh J, et al. Ther Clin Risk Manag. 2013;9:177-90. doi: 10.2147/TCRM.S30947. Epub 2013 Apr 26.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2