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Terconazole

CAS号

67915-31-5

分子式

C26H31Cl2N5O3

主要靶点

Antifungal|Antifection

仅限科研使用

Cat No : CM00541

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Synonyms

inhibit|Gyno-Terazol|Fungal|14-α Demethylase|特康唑|曲康唑|Triaconazole|Terazol 3|Terazol 7|Terconazole|Inhibitor|R42470|R-42470|R 42470

验证数据展示

  • CAS No.: 67915-31-5

    Terconazole
    CAS#: 67915-31-5

产品信息

CAS号 67915-31-5
分子式 C26H31Cl2N5O3
主要靶点 Antifungal|Antifection
主要通路 微生物学|微生物学
分子量 532.46
纯度 99.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Gyno-Terazol|Fungal|14-α Demethylase|特康唑|曲康唑|Triaconazole|Terazol 3|Terazol 7|Terconazole|Inhibitor|R42470|R-42470|R 42470

体内活性

通常，每天一次，连续三天的阴道内使用0.8%的terconazole便足以保证7天的有效治疗期，原因是terconazole在阴道内能维持长时间的高浓度生物活性抗真菌水平。在任何浓度下，观察到terconazole均未有副作用[2]。

体外活性

Terconazole以浓度依赖的方式抑制Candida albicans ATCC 44859的生长，但在0.1至10 μM范围内对在促进细胞形态的培养基上生长的酵母的影响较小。不同Candida菌株和种类的酵母细胞存活能力对terconazole的敏感性存在差异。当C. albicans ATCC 44859在Eagle最小必需培养基上生长（该培养基促进菌丝体形成）时，对terconazole的敏感性显著提高。从0.1 μM Terconazole开始阻止菌丝体形成，至100 μM时可见完全坏死现象[1]。Terconazole在0.008至0.05 microgram/mL浓度下阻断酵母形态向菌丝体形态的形态转变[2]。

溶解度

DMSO:50 mg/mL (93.9 mM)

参考文献

1.Tolman EL, et al. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Antimicrob Agents Chemother. 1986 Jun;29(6):986-91.
2.Van Cutsem J, et al. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1200-6.

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