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Terconazole

Terconazole (Terazol 7) 是一种广谱抗真菌药物，用于研究阴道酵母菌感染。

CAS号

67915-31-5

分子式

C26H31Cl2N5O3

主要靶点

Antifungal|Antifection

仅限科研使用

Cat No : CM00541

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Synonyms

特康唑|Terazol 7|Triaconazole|Gyno-Terazol|Terazol 3|曲康唑|R42470

验证数据展示

  • CAS No.: 67915-31-5

    Terconazole
    CAS#: 67915-31-5

产品信息

Terconazole is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.

CAS号 67915-31-5
分子式 C26H31Cl2N5O3
主要靶点 Antifungal|Antifection
主要通路 微生物学
分子量 532.46
纯度 99.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 特康唑|Terazol 7|Triaconazole|Gyno-Terazol|Terazol 3|曲康唑|R42470

体内活性

A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days due to prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2].

体外活性

Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner but has modest effects at levels of 0.1 to 10 μM when the yeast is grown on media that favors the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2].

溶解度

DMSO:45 mg/mL(84.5 mM)

参考文献

1.Tolman EL, et al. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Antimicrob Agents Chemother. 1986 Jun;29(6):986-91.
2.Van Cutsem J, et al. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1200-6.

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