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Tenovin-1

CAS号

380315-80-0

分子式

C20H23N3O2S

主要靶点

p53|Autophagy|Sirtuin|Dehydrogenase|Mdm2

仅限科研使用

Cat No : CM05713

Print datasheet

Synonyms

Sirtuin|Tenovin1|Tenovin-1|Tenovin 1|p53|protein-deacetylating|Inhibitor|MDM-2/p53|MDM2|Mdm2|Autophagy|acetylation|inhibit|Dihydroorotate Dehydrogenase|DHODH|degradation

验证数据展示

  • CAS No.: 380315-80-0

    Tenovin-1
    CAS#: 380315-80-0

产品信息

CAS号 380315-80-0
分子式 C20H23N3O2S
主要靶点 p53|Autophagy|Sirtuin|Dehydrogenase|Mdm2
主要通路 自噬|凋亡|表观遗传|DNA 损伤和修复|凋亡|代谢
分子量 369.48
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Sirtuin|Tenovin1|Tenovin-1|Tenovin 1|p53|protein-deacetylating|Inhibitor|MDM-2/p53|MDM2|Mdm2|Autophagy|acetylation|inhibit|Dihydroorotate Dehydrogenase|DHODH|degradation

体内活性

Tenovin-1（10 μM）可使p53免于mdm 2介导的降解,但几乎不影响p53蛋白合成。作用于表达p53的肿瘤细胞时,Tenovin-1可抑制细胞生长,并诱导细胞凋亡。Tenovin-1是p53激活剂,处理2 h内即可提高p53蛋白的量。Tenovin-1不影响p53 mRNA水平。

体外活性

体内实验表明,Tenovin-1抑制BL2衍生的移植瘤生长.

溶解度

DMSO:9.2 mg/mL (25 mM)

细胞实验

Cell viability isdetermined by trypan blue exclusion, Giemsa staining, or MTT assays.(Only for Reference)

参考文献

1.Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2