• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Taxifolin

Taxifolin (Dihydroquercetin) 是一种天然类黄酮，具有抗纤维化作用。它是一种自由基清除剂，具有抗氧化能力。它有效抑制胶原酶，IC50为 193.3 μM，具有重要的抗酪氨酸酶活性。

CAS号

480-18-2

分子式

C15H12O7

主要靶点

Adrenergic Receptor|Autophagy|TNF|Tyrosinase|VEGFR

仅限科研使用

Cat No : CM01134

Print datasheet

Synonyms

紫杉叶素|(+)-Taxifolin|二氢槲皮素|Dihydroquercetin|(+)-Dihydroquercetin

验证数据展示

  • CAS No.: 480-18-2

    Taxifolin
    CAS#: 480-18-2

产品信息

Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.

CAS号 480-18-2
分子式 C15H12O7
主要靶点 Adrenergic Receptor|Autophagy|TNF|Tyrosinase|VEGFR
主要通路 自噬|G蛋白偶联受体|蛋白酪氨酸激酶|蛋白酶体|凋亡|血管生成|神经科学
分子量 304.25
纯度 98.21%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 紫杉叶素|(+)-Taxifolin|二氢槲皮素|Dihydroquercetin|(+)-Dihydroquercetin

靶点活性

collagenase:193.3 μM

体内活性

Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[5]. Metabolites with the same fragment pattern may have the same pharmacophore. Thus these metabolites may exert the same pharmacological effects as taxifolin through an additive effect on the same drug targets. This observation indicates that taxifolin is bioactive not only in the parent form, but also through its metabolites.

溶解度

Ethanol:56 mg/mL (184.1 mM),DMSO:56 mg/mL (184.1 mM),H2O:<1 mg/mL

参考文献

1.Makena PS, et al. Environ Mol Mutagen, 2009, 50(6), 451-459.
2.Lee SB, et al. Biol Pharm Bull, 2007, 30(6), 1074-1079.
3.Luo H, et al. Nutr Cancer, 2008, 60(6), 800-809.
4.Sharad Verma, et al. Journal of Applied Pharmaceutical Science. 2012, 2 (1): 41-46.
5.Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.
6.Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586.
7.Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2