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Taxifolin

CAS号

480-18-2

分子式

C15H12O7

主要靶点

Adrenergic Receptor|Autophagy|TNF|Tyrosinase|VEGFR

仅限科研使用

Cat No : CM01134

Print datasheet

Synonyms

Dihydroquercetin|inhibit|(+)-Taxifolin|(+)-Dihydroquercetin|antifibrotic|antioxidant|Adrenergic Receptor|AdrenergicReceptor|Autophagy|Beta-nerve growth factor|Collagenase Tyrosinase|Inhibitor|Tyrosinase|TNF-α|VEGFR2|β-adrenergic receptor|Taxifolin|二氢槲皮素|紫杉叶素

验证数据展示

  • CAS No.: 480-18-2

    Taxifolin
    CAS#: 480-18-2

产品信息

CAS号 480-18-2
分子式 C15H12O7
主要靶点 Adrenergic Receptor|Autophagy|TNF|Tyrosinase|VEGFR
主要通路 G 蛋白偶联受体|神经科学|蛋白酶体|凋亡|血管生成|蛋白酪氨酸激酶|自噬
分子量 304.25
纯度 98.9%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Dihydroquercetin|inhibit|(+)-Taxifolin|(+)-Dihydroquercetin|antifibrotic|antioxidant|Adrenergic Receptor|AdrenergicReceptor|Autophagy|Beta-nerve growth factor|Collagenase Tyrosinase|Inhibitor|Tyrosinase|TNF-α|VEGFR2|β-adrenergic receptor|Taxifolin|二氢槲皮素|紫杉叶素

靶点活性

Collagenase:193.3 μM

体内活性

Taxifolin易于代谢，其代谢产物是体内主要存在形式，尽管关于Taxifolin在体内代谢的信息有限[5]。具有相同片段模式的代谢产物可能具有相同的药效团。因此，这些代谢产物可能通过对相同化合物靶点的加成效应，发挥与taxifolin相同的药理作用。这一观察表明，taxifolin不仅在母体形式中具有生物活性，也通过其代谢产物具有生物活性。

溶解度

Ethanol:56 mg/mL (184.1 mM);DMSO:65 mg/mL (213.64 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Makena PS, et al. Environ Mol Mutagen, 2009, 50(6), 451-459.
2.Lee SB, et al. Biol Pharm Bull, 2007, 30(6), 1074-1079.
3.Luo H, et al. Nutr Cancer, 2008, 60(6), 800-809.
4.Sharad Verma, et al. Journal of Applied Pharmaceutical Science. 2012, 2 (1): 41-46.
5.Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.
6.Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586.
7.Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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