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Taurodeoxycholic acid sodium hydrate

Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。

CAS号

110026-03-4

分子式

C26H47NNaO7S

主要靶点

Caspase|Apoptosis

仅限科研使用

Cat No : CM03302

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Synonyms

Taurohyodeoxycholic acid sodium salt|Taurohyodeoxycholic acid sodium salt|Taurodeoxychloic Acid sodium hydrate|牛磺猪去氧胆酸|Sodium taurodeoxycholate monohydrate|Sodium taurodeoxycholate monohydrate|Taurodeoxychloic Acid sodium hydrate

验证数据展示

  • CAS No.: 110026-03-4

    Taurodeoxycholic acid sodium hydrate
    CAS#: 110026-03-4

产品信息

Taurodeoxycholic acid sodium hydrate, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.

CAS号 110026-03-4
分子式 C26H47NNaO7S
主要靶点 Caspase|Apoptosis
主要通路 蛋白酶体|凋亡
分子量 540.71
纯度 98.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Taurohyodeoxycholic acid sodium salt|Taurohyodeoxycholic acid sodium salt|Taurodeoxychloic Acid sodium hydrate|牛磺猪去氧胆酸|Sodium taurodeoxycholate monohydrate|Sodium taurodeoxycholate monohydrate|Taurodeoxychloic Acid sodium hydrate

体内活性

At all infusion rates, taurohyodeoxycholic acid caused a greater (P < 0.001) secretion of biliary lecithin compared to the other bile salts. There were no significant differences in the biliary secretion of cholesterol and proteins. Electron microscopy showed the recruitment of vesicles and lamellar bodies around and within bile canaliculi. In conclusion, taurohyodeoxycholic promotes a biliary lecithin secretion greater than expected from physicochemical predictions, representing a novel secretory property with potential pharmacological relevance[1].

溶解度

DMSO:125 mg/mL (231.18 mM)

参考文献

1.Angelico M , Baiocchi L , Nistri A , et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat[J]. Digestive Diseases & Sciences, 1994, 39(11):2389-2397.
2.Roda A , Piazza F , Baraldini M , et al. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid–induced cholestasis in the rat[J]. Hepatology, 1998, 27.

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