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Taurodeoxycholic acid sodium hydrate

CAS号

110026-03-4

分子式

C26H46NNaO7S

主要靶点

Caspase|Apoptosis

仅限科研使用

Cat No : CM03302

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Synonyms

inhibit|Inhibitor|Sodium taurodeoxycholate|Sodium taurodeoxycholate monohydrate|Sodium taurodeoxycholate monohydrate|Sodium taurodeoxycholate Monohydrate|Taurodeoxychloic Acid sodium hydrate|Taurodeoxychloic Acid sodium hydrate|Taurodeoxychloic Acid sodium Hydrate|Taurohyodeoxycholic acid sodium|Taurohyodeoxycholic acid sodium salt|Taurohyodeoxycholic acid sodium salt|Taurodeoxycholic acid sodium|Taurodeoxycholic acid sodium Hydrate|Taurodeoxycholic acid sodium hydrate|牛磺猪去氧胆酸|Apoptosis|Caspase

验证数据展示

  • CAS No.: 110026-03-4

    Taurodeoxycholic acid sodium hydrate
    CAS#: 110026-03-4

产品信息

CAS号 110026-03-4
分子式 C26H46NNaO7S
主要靶点 Caspase|Apoptosis
主要通路 蛋白酶体|凋亡|凋亡
分子量 539.70
纯度 98.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Inhibitor|Sodium taurodeoxycholate|Sodium taurodeoxycholate monohydrate|Sodium taurodeoxycholate monohydrate|Sodium taurodeoxycholate Monohydrate|Taurodeoxychloic Acid sodium hydrate|Taurodeoxychloic Acid sodium hydrate|Taurodeoxychloic Acid sodium Hydrate|Taurohyodeoxycholic acid sodium|Taurohyodeoxycholic acid sodium salt|Taurohyodeoxycholic acid sodium salt|Taurodeoxycholic acid sodium|Taurodeoxycholic acid sodium Hydrate|Taurodeoxycholic acid sodium hydrate|牛磺猪去氧胆酸|Apoptosis|Caspase

体内活性

在所有注射速率下，taurohyodeoxycholic acid导致胆固醇磷脂 (lecithin) 的分泌量显著大于其他胆盐 (P < 0.001)。胆汁中胆固醇和蛋白质的分泌量没有显著差异。电子显微镜观察显示，囊泡和层状体在胆管周围和内部聚集。总之，Dehydrocavidine 促进的胆固醇磷脂分泌量超出了物理化学预测，表明了一种具有潜在药理学相关性的新型分泌特性[1]。

溶解度

DMSO:125 mg/mL (231.61 mM)

参考文献

1.Angelico M , Baiocchi L , Nistri A , et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat[J]. Digestive Diseases & Sciences, 1994, 39(11):2389-2397.
2.Roda A , Piazza F , Baraldini M , et al. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid–induced cholestasis in the rat[J]. Hepatology, 1998, 27.

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