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验证数据展示

  • WB analysis of HeLa using 22381-1-AP (same clone as 22381-1-PBS)

    WB analysis of HeLa using 22381-1-AP (same clone as 22381-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 22381-1-AP (TTI1 antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22381-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 22381-1-AP (same clone as 22381-1-PBS)

    IP experiment of HeLa using 22381-1-AP (same clone as 22381-1-PBS)

    IP result of anti-TTI1 (IP:22381-1-AP, 4ug; Detection:22381-1-AP 1:1000) with HeLa cells lysate 1600ug. This data was developed using the same antibody clone with 22381-1-PBS in a different storage buffer formulation.

  • WB analysis using 22381-1-AP (same clone as 22381-1-PBS)

    WB analysis using 22381-1-AP (same clone as 22381-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22381-1-AP (TTI1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22381-1-PBS in a different storage buffer formulation.

TTI1 Polyclonal antibody, PBS Only

TTI1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 22381-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IP, Indirect ELISA

别名

KIAA0406, Tel two interacting protein 1, TELO2-interacting protein 1 homolog

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

22381-1-PBS targets TTI1 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag17697

Product name: Recombinant human KIAA0406 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 740-1089 aa of BC013755

Sequence: DVLATLDQFYDKRAASFVSVLHALMAALAQWFPDTGNLGHLQEQSLGEEGSHLNQRPAALEKSTTTAEDIEQFLLNYLKEKDVADGNVSDFDNEEEEQSVPPKVDENDTRPDVEPPLPLQIQIAMDVMERCIHLLSDKNLQIRLKVLDVLDLCVVVLQSHKNQLLPLAHQAWPSLVHRLTRDAPLAVLRAFKVLRTLGSKCGDFLRSRFCKDVLPKLAGSLVTQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCERLDLGEGDLNKVADACLIYLSVKQPVKLQEAARSVFLHLMKVDPDSTWFLLNELYCPVQFTPPHPSLHPVQLHGASGQQNPYTTNVLQLLKELQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 KIAA0406
别名 KIAA0406, Tel two interacting protein 1, TELO2-interacting protein 1 homolog
计算分子量 1089 aa, 122 kDa
观测分子量 120 kDa
GenBank蛋白编号BC013755
基因名称 TTI1
Gene ID (NCBI) 9675
RRIDAB_2879094
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen Affinity purified
UNIPROT IDO43156
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Telomere maintenance 2-interacting protein 1 (TTI1), also known as KIAA0406 or SMG10, is one of the members of the conserved Triple T (TTT) complex, which is composed of telo a regulator of DNA damage and repair. TTI1 is expressed in numerous organisms and is assumed to play a central role in regulating a wide spectrum of DNA damage responses, telomere maintenance, and checkpoint signaling (PMID: 20427287). Knockdown of Tti1 suppresses phosphorylation of both mTORC1 substrates (S6K1 and 4E-BP1) and an mTORC2 substrate (Akt) (PMID: 40514657)

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