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验证数据展示

  • WB analysis of mouse testis using 15941-1-AP (same clone as 15941-1-PBS)

    WB analysis of mouse testis using 15941-1-AP (same clone as 15941-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 15941-1-AP (TMEM50B antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15941-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 15941-1-AP (same clone as 15941-1-PBS)

    IHC staining of mouse brain using 15941-1-AP (same clone as 15941-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 15941-1-AP (TMEM50B antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15941-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 15941-1-AP (same clone as 15941-1-PBS)

    IHC staining of mouse brain using 15941-1-AP (same clone as 15941-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 15941-1-AP (TMEM50B antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15941-1-PBS in a different storage buffer formulation.

TMEM50B Polyclonal antibody, PBS Only

TMEM50B Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 15941-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

15941-1-PBS targets TMEM50B in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag8220

Product name: Recombinant human TMEM50B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-158 aa of BC000569

Sequence: MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNTDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transmembrane protein 50B
别名
计算分子量 15 kDa
观测分子量 14 kDa, 30 kDa, 50 kDa
GenBank蛋白编号BC000569
基因名称 TMEM50B
Gene ID (NCBI) 757
RRIDAB_2205161
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP56557
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TMEM50B, originally referred to as C21orf4, is a predicted transmembrane protein, estimated to contain four transmembrane-spanning domains with both the carboxy- and amino-terminals being cytoplasmic (PMID: 10077530; 18541381). Human TMEM50B shares sequence homologies of around 90-100% with mouse and rat Tmem50b. In a Down syndrome mouse model, Ts1Cje, Tmem50b is shown to be one of the few genes significantly over-expressed during cerebellar development (PMID: 15590701). It has been reported that rodent Tmem50b is a developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia (PMID: 18541381). TMEM50B can exist as a dimer and a trimer conformation (PMID: 18541381).

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