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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
0
Conjugate
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验证数据展示

  • WB analysis using 27757-1-AP (same clone as 27757-1-PBS)

    WB analysis using 27757-1-AP (same clone as 27757-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27757-1-AP (TMCO1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27757-1-PBS in a different storage buffer formulation.

  • IHC staining of human intrahepatic cholangiocarcinoma using 27757-1-AP (same clone as 27757-1-PBS)

    IHC staining of human intrahepatic cholangiocarcinoma using 27757-1-AP (same clone as 27757-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 27757-1-AP (TMCO1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27757-1-PBS in a different storage buffer formulation.

TMCO1 Polyclonal antibody, PBS Only

TMCO1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27757-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

UNQ151/PRO177, TMCC4, RP11 466F5.7, PNAS 136, PCIA3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

27757-1-PBS targets TMCO1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 TMCO1 fusion protein Ag26278 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transmembrane and coiled-coil domains 1
别名 UNQ151/PRO177, TMCC4, RP11 466F5.7, PNAS 136, PCIA3
计算分子量 21 kDa
观测分子量 21 kDa
GenBank蛋白编号NM_019026
基因名称 TMCO1
Gene ID (NCBI) 54499
RRIDAB_2880962
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9UM00
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TMCO1, also known as TMCC4, PNAS-10, and PNAS-136, is a 188 amino acid protein, which is Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). TMCO1 as a Calcium-selective channel is required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, TMCO1, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).