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TLR1

TLR1 是细胞穿透 Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop 的小分子模拟物，能够阻碍 IL-1 受体介导的反应。

CAS号

566914-00-9

分子式

C18H26N2O2

主要靶点

MyD88|Others

仅限科研使用

Cat No : CM10835

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Synonyms

N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺

验证数据展示

  • CAS No.: 566914-00-9

    TLR1
    CAS#: 566914-00-9

产品信息

TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.

CAS号 566914-00-9
分子式 C18H26N2O2
主要靶点 MyD88|Others
主要通路 免疫与炎症|其他
分子量 302.41
纯度 98.51%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺

体内活性

TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.).

体外活性

In EL4 thymoma cells and in freshly isolated murine lymphocytes, TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in a concentration-dependent manner.

溶解度

DMSO:30 mg/mL (99.2 mM)

参考文献

1.Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2