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TKIM

CAS号

326921-25-9

分子式

C18H14ClN3O2S

主要靶点

Potassium Channel

仅限科研使用

Cat No : CM14807

Print datasheet

Synonyms

TREK-1|TKIM|Potassium Channel|PotassiumChannel

验证数据展示

  • CAS No.: 326921-25-9

    TKIM
    CAS#: 326921-25-9

产品信息

CAS号 326921-25-9
分子式 C18H14ClN3O2S
主要靶点 Potassium Channel
主要通路 离子通道
分子量 371.84
纯度 99.47%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 TREK-1|TKIM|Potassium Channel|PotassiumChannel

体外活性

TKIM与TREK-1的IM状态的口袋结合，这与常见抑制剂结合到非活动状态的通道的方式不同。总体而言，识别了一个异构配体结合位点和TREK-1的新机制抑制剂，表明离子通道的IM状态可能是发现异构调节剂的有前景的可药用目标。

溶解度

DMSO:30 mg/mL (80.68 mM)

参考文献

1.Ma Y , Luo Q , Fu J , et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating[J]. Journal of Medicinal Chemistry, 2020.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2