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TH1020

CAS号

1841460-82-9

分子式

C23H15N7S2

主要靶点

TLR|Antibacterial

仅限科研使用

Cat No : CM06658

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Synonyms

Inhibitor|interaction|protein-protein|TH1020|TH-1020|TH 1020|TLR5|TLR|Toll-like Receptor (TLR)|TNF-α|inhibit|flagellin|Bacterial

验证数据展示

  • CAS No.: 1841460-82-9

    TH1020
    CAS#: 1841460-82-9

产品信息

CAS号 1841460-82-9
分子式 C23H15N7S2
主要靶点 TLR|Antibacterial
主要通路 免疫与炎症|微生物学
分子量 453.54
纯度 99.23%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|interaction|protein-protein|TH1020|TH-1020|TH 1020|TLR5|TLR|Toll-like Receptor (TLR)|TNF-α|inhibit|flagellin|Bacterial

靶点活性

TLR5/flagellin complex:0.85 μM (IC50)

体内活性

TH1020通过抑制由TLR5/flagellin复合体介导的下游TNF-α信号传导途径的表达。基于分子对接模拟，TH1020被认为是与flagellin竞争并破坏其与TLR5的结合。因此，TH1020为研究这一重要的蛋白质-蛋白质相互作用提供了急需的分子探针，并为发现针对TLR5的新型化合物提供了先导化合物。

溶解度

DMSO:4.54 mg/mL (10 mM)

参考文献

1.Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. ChemMedChem. 2016 Apr 19;11(8):822-6.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2