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验证数据展示

  • IHC staining of human lung cancer using 11407-1-AP (same clone as 11407-1-PBS)

    IHC staining of human lung cancer using 11407-1-AP (same clone as 11407-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11407-1-AP (TACC2 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11407-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 11407-1-AP (same clone as 11407-1-PBS)

    IHC staining of human lung cancer using 11407-1-AP (same clone as 11407-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11407-1-AP (TACC2 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11407-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse testis using 11407-1-AP (same clone as 11407-1-PBS)

    WB analysis of mouse testis using 11407-1-AP (same clone as 11407-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 11407-1-AP (TACC2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11407-1-PBS in a different storage buffer formulation.

TACC2 Polyclonal antibody, PBS Only

TACC2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 11407-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

11407-1-PBS targets TACC2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 TACC2 fusion protein Ag1923 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transforming, acidic coiled-coil containing protein 2
别名
计算分子量 2948 aa, 309 kDa
观测分子量 73 kDa
GenBank蛋白编号BC015736
基因名称 TACC2
Gene ID (NCBI) 10579
RRIDAB_2200456
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO95359
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Transforming acidic coiled-coil (TACC) proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. TACC2, also known as anti-zuai-1 (AZU-1), was abundantly expressed in non- and premalignant cells and tissues but was appreciably reduced in breast tumor cell types and in primary tumors, thus TACC2 may act as a tumor suppressor protein and represent a tumor progression marker. Several transcript variants encoding different isoforms have been found for this gene. Chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubule and the kinetochore. Centrosomal TACC2 plays a role in organizing centrosomal microtubules and is required for mitotic spindle maintenance.