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T0070907

T0070907 是一种有效且特异性的 PPARγ 抑制剂，Ki 值为1 nM，其选择性比 PPARα 和 PPARδ 高 800 倍以上。

CAS号

313516-66-4

分子式

C12H8ClN3O3

主要靶点

PPAR

仅限科研使用

Cat No : CM06134

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Synonyms

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  • CAS No.: 313516-66-4

    T0070907
    CAS#: 313516-66-4

产品信息

T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.

CAS号 313516-66-4
分子式 C12H8ClN3O3
主要靶点 PPAR
主要通路 DNA损伤和修复|代谢
分子量 277.66
纯度 99.95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

PPARγ:1 nM

体内活性

T0070907 can attenuate the beneficial effects of lipopolysaccharide pretreatment, such as significantly improving renal insufficiency, reducing hepatocyte damage and circulatory failure, and reducing plasma interleukin-1 elevation caused by severe endotoxemia.

溶解度

1eq. HCl:27.8 mg/mL (100 mM),DMSO:27.8 mg/mL (100 mM)

细胞实验

MTS assay(Only for Reference)

参考文献

1.Lee G et al. J Biol Chem, 2002, 277(22), 19649-19657.
2.Zaytseva YY et al. Anticancer Res, 2011, 31(3), 813-823.
3.Collin M et al. Crit Care Med, 2006, 34(4), 1131-1138.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2