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Sunset Yellow FCF

Sunset Yellow FCF (Sunset yellow) 是一种橙色偶氮染料，吸光度具有pH 依赖性。Sunset Yellow FCF 可在食品，化妆品和药品中使用，在许多食品中用作着色剂食品添加剂，它们可能具有细胞毒性和遗传毒性，因此在使用这些材料作为食品添加剂时必须小心。

CAS号

2783-94-0

分子式

C16H12N2Na2O7S2

主要靶点

Androgen Receptor

仅限科研使用

Cat No : CM00535

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Synonyms

Food Yellow 3|Orange Yellow S|CI 15985|Sunset yellow

验证数据展示

  • CAS No.: 2783-94-0

    Sunset Yellow FCF
    CAS#: 2783-94-0

产品信息

Sunset Yellow FCF is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used as a colorant food additive in many food products.They may be cytotoxic and genotoxic, so care must be taken when using these materials as food additives.

CAS号 2783-94-0
分子式 C16H12N2Na2O7S2
主要靶点 Androgen Receptor
主要通路 内分泌与激素
分子量 454.39
纯度 98.03%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Food Yellow 3|Orange Yellow S|CI 15985|Sunset yellow

体内活性

Sunset yellow FCF (0.325 mg/kg; mice) induces chromosomal aberrations in somatic and germ cells and morphological abnormalities in sperm in mice, but it is not genotoxic in a micronucleus gut assay in mice when administered at doses up to 2,000 mg/kg.[4]

体外活性

Sunset Yellow FCF (250 μg/ml) reduces the LPS-induced proliferation of isolated mouse splenocytes, as well as inhibits the proliferation of isolated mouse splenocytes in an allogeneic mixed lymphocyte reaction.[3]

溶解度

DMSO:90 mg/mL (198.95 mM),H2O:90.0 mg/mL (199.0 mM),Sonification is recommended.

参考文献

1.Kus E, et al. Genotoxic and cytotoxic effects of Sunset Yellow and Brilliant Blue, colorant food additives, on human blood lymphocytes.Pak J Pharm Sci. 2015 Jan;28(1):227-30.
2.Ghoneim M M, et al. Electro-Fenton oxidation of Sunset Yellow FCF azo-dye in aqueous solutions. Desalination, 2011, 274(1-3): 22-30.
3.Yadav A, et al. Sunset yellow FCF, a permitted food dye, alters functional responses of splenocytes at non-cytotoxic dose. Toxicol Lett. 2013;217(3):197-204.
4.Sayed HM, et al. The modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male mice. Mutat Res. 2012;744(2):145-153.

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