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Src Inhibitor 1

CAS号

179248-59-0

分子式

C22H19N3O3

主要靶点

Src

仅限科研使用

Cat No : CM06527

Print datasheet

Synonyms

inhibit|Inhibitor|Lck|Src|Src Inhibitor1|Src Inhibitor-1|Src Kinase Inhibitor1|Src Kinase Inhibitor-1|Src Kinase Inhibitor 1|Src Inhibitor 1|Src-l1

验证数据展示

  • CAS No.: 179248-59-0

    Src Inhibitor 1
    CAS#: 179248-59-0

产品信息

CAS号 179248-59-0
分子式 C22H19N3O3
主要靶点 Src
主要通路 蛋白酪氨酸激酶|血管生成
分子量 373.4
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Inhibitor|Lck|Src|Src Inhibitor1|Src Inhibitor-1|Src Kinase Inhibitor1|Src Kinase Inhibitor-1|Src Kinase Inhibitor 1|Src Inhibitor 1|Src-l1

靶点活性

Lck:88nM|Src:44 nM

体外活性

Src-I1在激酶的ATP和肽结合位点具有竞争性作用。其IC50值对Src和Lck分别为44 nM和88 nM[1]。Src-I1是一种强效的Src抑制剂（IC50=0.18 μM），同时也能以类似Src的效力抑制Src家族的其他成员。此外，它对CHK2的抑制效力与对Src相当，而对Aurora B的抑制效力略低[2]。

溶解度

DMSO:3.73 mg/mL (10 mM)

参考文献

1.Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry. 2001 Jun 19;40(24):7084-91.
2.Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2