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L-Ascorbic acid sodium salt

L-Ascorbic acid sodium salt (Vitamin C sodium salt) 是一种电子供体，是一种内源性抗氧化剂。它还是一种胶原沉积促进剂和弹性生成抑制剂。它选择性抑制 Cav3.2 通道(Cav3.2 channels)，IC50为 6.5 μM。

CAS号

134-03-2

分子式

C6H8NaO6

主要靶点

Apoptosis|Calcium Channel|Endogenous Metabolite|Reactive Oxygen Species|Others

仅限科研使用

Cat No : CM00502

Print datasheet

Synonyms

L-Ascorbic acid sodium|Sodium ascorbate|(+)-Sodium L-ascorbate|Vitamin C sodium salt|抗坏血酸钠|维生素C钠|Sodium L-ascorbate

验证数据展示

  • CAS No.: 134-03-2

    L-Ascorbic acid sodium salt
    CAS#: 134-03-2

产品信息

Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

CAS号 134-03-2
分子式 C6H8NaO6
主要靶点 Apoptosis|Calcium Channel|Endogenous Metabolite|Reactive Oxygen Species|Others
主要通路 NF-κB信号通路|代谢|离子通道|其他|免疫与炎症|凋亡
分子量 199.11
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 L-Ascorbic acid sodium|Sodium ascorbate|(+)-Sodium L-ascorbate|Vitamin C sodium salt|抗坏血酸钠|维生素C钠|Sodium L-ascorbate

体内活性

Tg rats treated with sodium?L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium?L-ascorbate (15.4%). Independent of the sodium?L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium?L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium?L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].

体外活性

Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. [1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. [2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. [3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. [4]

溶解度

DMSO:10 mM,H2O:198.9 mM

参考文献

1.Noto V, et al. Cancer, 1989, 63(5), 901-906.
2.De Loecker W, et al. Anticancer Res, 1993, 13(1), 103-106.
3.Sakagami H, et al. Life Sci, 1996, 58(14), 1131-1138.
4.Singh NP, et al. Mutat Res, 1997, 375(2), 195-203.
5.Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2