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Sennoside A

Sennoside A (NSC-112929) 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷，抑制 HIV-1 复制。

CAS号

81-27-6

分子式

C42H38O20

主要靶点

HIV Protease|MAO

仅限科研使用

Cat No : CM01041

Print datasheet

Synonyms

番泻苷A|NSC 112929|番泻苷 A

验证数据展示

  • CAS No.: 81-27-6

    Sennoside A
    CAS#: 81-27-6

产品信息

Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.

CAS号 81-27-6
分子式 C42H38O20
主要靶点 HIV Protease|MAO
主要通路 代谢|蛋白酶体|微生物学|神经科学
分子量 862.74
纯度 95.95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 番泻苷A|NSC 112929|番泻苷 A

靶点活性

MAO:17 μM

体内活性

LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.). [3]

体外活性

Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine through regulating the spontaneous motility of colon. [2] It mildly inhibits bovine serum monoamine oxidase with IC50 of 17 μM. [1]

溶解度

Ethanol:<1 mg/mL,H2O:<1 mg/mL,DMSO:95 mg/mL (110.1 mM)

参考文献

1.Hiraoka A, et al. Chem Pharm Bull, 1989, 37(10), 2744-2746.
2.Kobayashi M, et al. Basic Clin Pharmacol Toxicol, 2007, 101(2), 121-126.
3.Mengs U, et al. Pharmacology, 1988, 36(Suppl. 1), 180-187.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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