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Sabatolimab

Sabatolimab (MBG453) 是一种靶向 TIM-3的人源化 IgG4 (S228P) 抗体，是一种有效的调节适应性和先天免疫反应的抑制性受体。Sabatolimab 具有潜在的免疫抑制活性，可选择性与免疫细胞和骨髓细胞上的 TIM-3 结合。

CAS号

2252262-24-9

分子式

主要靶点

Others

仅限科研使用

Cat No : CM08159

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Synonyms

NVP-MBG453|MBG453

验证数据展示

  • CAS No.: 2252262-24-9

    Sabatolimab
    CAS#: 2252262-24-9

产品信息

Sabatolimab (MBG453), a humanized IgG4 (S228P) antibody targeting TIM-3, is a potent inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab has potential immunosuppressive activity and selectively binds to TIM-3 on immune cells and bone marrow cells.

CAS号 2252262-24-9
分子式
主要靶点 Others
主要通路 其他
分子量
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名 NVP-MBG453|MBG453

参考文献

1.Andrew M. Brunner, et al. Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients with Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS): Updated Results from a Phase 1b Study. Blood (2020) 136 (Supplement 1): 1–2.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2