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SRT 1460

SRT 1460 是一种有效的SIRT1激动剂，其EC1.5值为 2.9 μM。

CAS号

925432-73-1

分子式

C26H29N5O4S

主要靶点

Sirtuin

仅限科研使用

Cat No : CM06447

Print datasheet

Synonyms

3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-B]噻唑-6-基)苯基)苯甲酰胺|SRT1460

验证数据展示

  • CAS No.: 925432-73-1

    SRT 1460
    CAS#: 925432-73-1

产品信息

SRT 1460 is a SIRT1 activator.

CAS号 925432-73-1
分子式 C26H29N5O4S
主要靶点 Sirtuin
主要通路 表观遗传|DNA损伤和修复
分子量 507.6
纯度 97.62%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-B]噻唑-6-基)苯基)苯甲酰胺|SRT1460

靶点活性

SIRT1:2.9 μM (EC1.5)

体外活性

SRT1460 inhibited cell growth and survival of pancreatic cancer cells[1].

溶解度

DMSO:5.08 mg/mL (10 mM),Sonification is recommended.

细胞实验

Patu8988t (pancreatic cancer cells), Panc-1 (pancreatic cancer cells), SU86.86 (pancreatic cancer cells), HPDE cells.?Concentration:2 μM, 4 μM, 6 μM.?Incubation Time:72 hours[1]

参考文献

1.Chini CC, Espindola-Netto JM, Mondal G,et al. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway[J]. clinical cancer research, 2016, 22(10):2496-2507.
2.SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.J Biol Chem. 2010 Mar 12;285(11):8340-51.Pacholec M, Bleasdale JE, Chrunyk B,et al.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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