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验证数据展示

  • IHC staining of mouse liver using 22765-1-AP (same clone as 22765-1-PBS)

    IHC staining of mouse liver using 22765-1-AP (same clone as 22765-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 22765-1-AP (SPRY4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22765-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 22765-1-AP (same clone as 22765-1-PBS)

    IHC staining of mouse liver using 22765-1-AP (same clone as 22765-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 22765-1-AP (SPRY4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22765-1-PBS in a different storage buffer formulation.

  • WB analysis of A375 using 22765-1-AP (same clone as 22765-1-PBS)

    WB analysis of A375 using 22765-1-AP (same clone as 22765-1-PBS)

    A375 cells were subjected to SDS PAGE followed by western blot with 22765-1-AP (SPRY4 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22765-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

SPRY4 Polyclonal antibody, PBS Only

SPRY4 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 22765-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Spry-4, Spry 4, sprouty homolog 4 (Drosophila), Protein sprouty homolog 4, HH17

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

22765-1-PBS targets SPRY4 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 SPRY4 fusion protein Ag18574 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sprouty homolog 4 (Drosophila)
别名 Spry-4, Spry 4, sprouty homolog 4 (Drosophila), Protein sprouty homolog 4, HH17
计算分子量 299 aa, 33 kDa
观测分子量 35-38 kDa
GenBank蛋白编号BC125095
基因名称 SPRY4
Gene ID (NCBI) 81848
RRIDAB_2879163
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9C004
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SPRY4, also named as Protein sprouty homolog 4, is a 299 amino acid protein, which contains one SPR (sprouty) domain and belongs to the sprouty family. SPRY4 Suppresses the INS receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. SPRY4 has a cellular function to regulate the actin cytoskeleton, independent of its inhibitory activity on the Ras/MAP kinase signalling. SPRY1, SPRY2, SPRY3, SPRY4, are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway.