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SPD304 dihydrochloride

SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂，IC50 为 22 µM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。

CAS号

1049741-03-8

分子式

C32H34Cl2F3N3O2

主要靶点

TNF

仅限科研使用

Cat No : CM11653

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Synonyms

验证数据展示

  • CAS No.: 1049741-03-8

    SPD304 dihydrochloride
    CAS#: 1049741-03-8

产品信息

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.

CAS号 1049741-03-8
分子式 C32H34Cl2F3N3O2
主要靶点 TNF
主要通路 凋亡
分子量 620.53
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

TNFα:22 µM

体外活性

The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p−RIP3 (1.4−fold) compared to GA and promote the activation of caspase 8[4].

溶解度

DMSO:6.2 mg/mL (10 mM)

参考文献

1.Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005.
2.Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805.
3.Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424.
4.Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.

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