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SNC 80

CAS号

156727-74-1

分子式

C28H39N3O2

主要靶点

Opioid Receptor

仅限科研使用

Cat No : CM10738

Print datasheet

Synonyms

NIH10815|NIH-10815|NIH 10815|Opioid Receptor|OpioidReceptor|δ-opioid receptor|SNC80|Snc-80|SNC-80|SNC 80

验证数据展示

  • CAS No.: 156727-74-1

    SNC 80
    CAS#: 156727-74-1

产品信息

CAS号 156727-74-1
分子式 C28H39N3O2
主要靶点 Opioid Receptor
主要通路 G 蛋白偶联受体|神经科学|内分泌与激素
分子量 449.63
纯度 98.67%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 NIH10815|NIH-10815|NIH 10815|Opioid Receptor|OpioidReceptor|δ-opioid receptor|SNC80|Snc-80|SNC-80|SNC 80

体内活性

SNC80 (10 mg/kg; intraperitoneal injection; once) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan in C57BL6/J mice [1].

体外活性

SNC80 selectively activates μ-δ heteromer in HEK293 cells, EC50 = 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors [4].

溶解度

DMSO:1 mg/mL (2.22 mM)

参考文献

1.Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr;148:77-86.
2.Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66.
3.zinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37(14):2125-8.
4.Metcalf MD, et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.
5.Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159.
6.ripps IJ, et al. Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175(6):891-901.

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