验证数据展示
产品信息
22815-1-PBS targets SLCO1B3/OATP1B3 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag18940 Product name: Recombinant human SLCO1B3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 11-48 aa of BC105597 Sequence: AESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIM 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | solute carrier organic anion transporter family, member 1B3 |
| 别名 | |
| 计算分子量 | 702 aa, 77 kDa |
| 观测分子量 | 70-75 kDa |
| GenBank蛋白编号 | BC105597 |
| 基因名称 | SLCO1B3 |
| Gene ID (NCBI) | 28234 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9NPD5 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SLCO1B3, also known as OATP8 or OATP1B3, is a member of Organic Anion Transporting Polypeptides (OATPs) which are sodium-independent organic anion transporters mediating the uptake of a wide range of structurally diverse endogenous and exogenous compounds including bile acids, hormone conjugates, peptides, toxins, as well as a multitude of therapeutic drugs. SLCO1B3 is specifically expressed in liver under normal condition, while its expression has also been observed in cancer tissues like colon, prostate and pancreas. SLCO1B3 is a glycosylated protein and can be detected in the non-glycosylated form at 70-75 kDa(PMID: 21278621).
