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SKF-96365 hydrochloride

CAS号

130495-35-1

分子式

C22H27ClN2O3

主要靶点

Autophagy|Potassium Channel|Calcium Channel|TRP/TRPV Channel|Apoptosis

仅限科研使用

Cat No : CM03250

Print datasheet

Synonyms

CRAC Channel|inhibit|Autophagy|cancer|CalciumChannel|Calcium release-activated channels|Calcium Channel|Ca2+ release-activated Ca2+ channels|cell-cycle|colorectal|1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑|anti-neoplastic|Apoptosis|arrest|SKF96365|SKF-96365|SKF96365 Hydrochloride|SKF96365 hydrochloride|SKF-96365 Hydrochloride|SKF 96365|SKF 96365 Hydrochloride|SKF 96365 hydrochloride|TRPVChannel|TRPV Channel|TRPChannel|TRP Channel|TRP|Transient receptor potential channels|Inhibitor|interval|KcsA|prolong|QTc|Potassium Channel|PotassiumChannel

验证数据展示

  • CAS No.: 130495-35-1

    SKF-96365 hydrochloride
    CAS#: 130495-35-1

产品信息

CAS号 130495-35-1
分子式 C22H27ClN2O3
主要靶点 Autophagy|Potassium Channel|Calcium Channel|TRP/TRPV Channel|Apoptosis
主要通路 离子通道|凋亡|离子通道|离子通道|代谢|自噬
分子量 402.91
纯度 99.85%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 CRAC Channel|inhibit|Autophagy|cancer|CalciumChannel|Calcium release-activated channels|Calcium Channel|Ca2+ release-activated Ca2+ channels|cell-cycle|colorectal|1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑|anti-neoplastic|Apoptosis|arrest|SKF96365|SKF-96365|SKF96365 Hydrochloride|SKF96365 hydrochloride|SKF-96365 Hydrochloride|SKF 96365|SKF 96365 Hydrochloride|SKF 96365 hydrochloride|TRPVChannel|TRPV Channel|TRPChannel|TRP Channel|TRP|Transient receptor potential channels|Inhibitor|interval|KcsA|prolong|QTc|Potassium Channel|PotassiumChannel

体内活性

SKF-96365处理在体外和体内抑制了钙/钙调蛋白依赖性蛋白激酶IIγ（CaMKIIγ）/AKT信号通路[4]。

体外活性

SKF-96365 在PC12细胞中对MPP+引起的损伤显示出保护作用，显著抑制了MPP+处理后PC12细胞的凋亡死亡，并且在PC12细胞中不影响MPP+诱导的坏死性死亡。由于其非选择性活性，SKF-96365已被证明对多种Ca2+通道有影响：它不仅能在常用测试浓度下阻断高电压激活（HVA）Ca2+通道，也能强效抑制在HEK293细胞中的低电压激活（LVA）T型Ca2+通道。SKF-96365对细胞内钙稳态的具体作用可能依赖于细胞类型和所使用的实验模型[2]。

溶解度

DMSO:60 mg/mL (148.92 mM);H2O:198.6 mM

细胞实验

To investigate whether SKF-96365 could protect PC12 cells from injury induced by MPP+ insult, cultured PC12 cells are pretreated with SKF-96365 in different concentrations (1 µM, 10 µM or 50 µM) 30 min before MPP+ addition. The cells viability is measured 24 h after MPP+ insult by using the cell proliferation reagent WST-1. (Only for Reference)

参考文献

1.Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475.
2.Chen T, et al. PLoS One. 2013, 8(1):e55601.
3.Yao H, et al. Cell Death Differ. 2009, 16(12):1681-1693.
4.Jing Z, et al. Cancer Lett. 2016, 372(2):226-38.

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