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SIRT5 inhibitor 1

CAS号

2166487-21-2

分子式

C31H39FN6O6S2

主要靶点

Sirtuin

仅限科研使用

Cat No : CM11639

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Synonyms

Sirtuin|SIRT5 inhibitor 1|SIRT-5 inhibitor 1

验证数据展示

  • CAS No.: 2166487-21-2

    SIRT5 inhibitor 1
    CAS#: 2166487-21-2

产品信息

CAS号 2166487-21-2
分子式 C31H39FN6O6S2
主要靶点 Sirtuin
主要通路 表观遗传|DNA 损伤和修复
分子量 674.81
纯度 98.06%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Sirtuin|SIRT5 inhibitor 1|SIRT-5 inhibitor 1

靶点活性

Sirtuin:0.11 μM |Sirtuin:0.11 μM

体外活性

SIRT5 inhibitor 1 is a very potent inhibitor of human sirtuin 5 deacylase(IC50 of 0.11 μM, >100-fold from compound.[1]

溶解度

DMSO:112.5 mg/mL (166.7 mM )

参考文献

1.Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 ; 56(47):14836-14841.
2.Molinari F, et al. SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes. Cells. 2021 ; 10(5):1126.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2