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SIRT5 inhibitor 1

SIRT5 inhibitor 1是一种高效且具有选择性的人类 Sirtuin 5脱酰基酶抑制剂（IC50：0.11μM）。SIRT5 inhibitor 1与衰老相关疾病有关。

CAS号

2166487-21-2

分子式

C31H39FN6O6S2

主要靶点

Sirtuin

仅限科研使用

Cat No : CM11639

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Synonyms

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  • CAS No.: 2166487-21-2

    SIRT5 inhibitor 1
    CAS#: 2166487-21-2

产品信息

SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases.

CAS号 2166487-21-2
分子式 C31H39FN6O6S2
主要靶点 Sirtuin
主要通路 表观遗传|DNA损伤和修复
分子量 674.81
纯度 98.06%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

Sirtuin:0.11 μM |Sirtuin:0.11 μM

体外活性

SIRT5 inhibitor 1 is a very potent inhibitor of human sirtuin 5 deacylase(IC50 of 0.11 μM, >100-fold from compound.[1]

溶解度

DMSO:112.5 mg/mL (166.7 mM ),Sonification is recommended.

参考文献

1.Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 ; 56(47):14836-14841.
2.Molinari F, et al. SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes. Cells. 2021 ; 10(5):1126.

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