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SHIN1

CAS号

2146095-85-2

分子式

C24H24N4O2

主要靶点

Others

仅限科研使用

Cat No : CM20763

Print datasheet

Synonyms

inhibit|Inhibitor|RZ 2994|RZ-2994|RZ2994|SHMT2|SHMT1|SHIN1|SHIN-1|SHIN 1

验证数据展示

  • CAS No.: 2146095-85-2

    SHIN1
    CAS#: 2146095-85-2

产品信息

CAS号 2146095-85-2
分子式 C24H24N4O2
主要靶点 Others
主要通路 其他
分子量 400.47
纯度 98.18， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Inhibitor|RZ 2994|RZ-2994|RZ2994|SHMT2|SHMT1|SHIN1|SHIN-1|SHIN 1

靶点活性

SHMT1:5 nM|SHMT2:13 nM

体外活性

SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50: 10 nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates [1].

溶解度

DMSO:50 mg/mL (124.85 mM)

参考文献

1.Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2