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SERCA2a activator 1

CAS号

2139330-34-8

分子式

C32H29N3O4S

主要靶点

Calcium Channel

仅限科研使用

Cat No : CM13567

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Synonyms

CalciumChannel|Calcium Channel|Ca2+ channels|Ca2+|Ca channels|diastolic|failure|heart|sarcoplasmic|SERCA2a|SERCA2a activator 1|SERCA-2a activator 1|systolic|phospholamban|reticulum|Inhibitor|inhibit

验证数据展示

  • CAS No.: 2139330-34-8

    SERCA2a activator 1
    CAS#: 2139330-34-8

产品信息

CAS号 2139330-34-8
分子式 C32H29N3O4S
主要靶点 Calcium Channel
主要通路 离子通道|代谢
分子量 551.66
纯度 99.52%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 CalciumChannel|Calcium Channel|Ca2+ channels|Ca2+|Ca channels|diastolic|failure|heart|sarcoplasmic|SERCA2a|SERCA2a activator 1|SERCA-2a activator 1|systolic|phospholamban|reticulum|Inhibitor|inhibit

体内活性

SERCA2a activator 1 (30mg/kg; intravenous injection; male Wistar rats) treatment obviously increases the diastolic function in anesthetized normal rats [1].

体外活性

SERCA2a activator 1 activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum vesicles but not that of skeletal muscle SR vesicles that lack phospholamban. SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation [1].

溶解度

DMSO:60 mg/mL (108.76 mM)

参考文献

1.Kaneko M, et al. A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban. Eur J Pharmacol. 2017 Nov 5;814:1-8.

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