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SCH 58261

CAS号

160098-96-4

分子式

C18H15N7O

主要靶点

Adenosine Receptor

仅限科研使用

Cat No : CM02538

Print datasheet

Synonyms

inhibit|A2A (rat)|A2A (bovine)|Adenosine Receptor|AdenosineReceptor|SCH 58261|SCH58261|SCH-58261|Inhibitor|P1 receptor

验证数据展示

  • CAS No.: 160098-96-4

    SCH 58261
    CAS#: 160098-96-4

产品信息

CAS号 160098-96-4
分子式 C18H15N7O
主要靶点 Adenosine Receptor
主要通路 G 蛋白偶联受体|神经科学
分子量 345.36
纯度 99.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|A2A (rat)|A2A (bovine)|Adenosine Receptor|AdenosineReceptor|SCH 58261|SCH58261|SCH-58261|Inhibitor|P1 receptor

靶点活性

A2A (rat):2.3 nM(Ki)|A2a (bovine):2.0 nM(Ki)

体内活性

In mice with Spinal cord injury, SCH58261 (0.01 mg/kg, i.p.) reduces demyelination and levels of TNF-α, Fas-L, PAR, Bax expression and activation of JNK MAPK. Chronic SCH58261 administration improves the neurological deficit up. [2] In rats with 6-OHDA-induced Parkinson's disease, SCH58261 (2 mg/kg, i.p.) improves the 6-OHDA-induced bradykinesia and motor disturbance. [3]

体外活性

SCH 58261 causes the inhibition of rabbit platelet aggregation and porcine coronary artery relaxation by antagonizing competitively the effects induced by CGS 21680. [1]

溶解度

DMSO:34.5 mg/mL (99.9 mM)

参考文献

1.Zocchi C, et al. J Pharmacol Exp Ther. 1996, 276(2), 398-404.
2.Paterniti I, et al. J Neuroinflammation. 2011, 8, 31.
3.Reyhani-Rad S, et al. Acta Cir Bras. 2016, 31(2), 133-137.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2