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SCH442416

CAS号

316173-57-6

分子式

C20H19N7O2

主要靶点

Adenosine Receptor

仅限科研使用

Cat No : CM02537

Print datasheet

Synonyms

inhibit|imaging|2-(2-呋喃基)-7-[3-(4-甲氧苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]三唑并[1,5-C]嘧啶-5-胺|Adenosine Receptor|AdenosineReceptor|A2A|adenosine|Inhibitor|P1 receptor|SCH 442416|SCH442416|SCH-442416

验证数据展示

  • CAS No.: 316173-57-6

    SCH442416
    CAS#: 316173-57-6

产品信息

CAS号 316173-57-6
分子式 C20H19N7O2
主要靶点 Adenosine Receptor
主要通路 神经科学|G 蛋白偶联受体
分子量 389.41
纯度 99.58%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|imaging|2-(2-呋喃基)-7-[3-(4-甲氧苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]三唑并[1,5-C]嘧啶-5-胺|Adenosine Receptor|AdenosineReceptor|A2A|adenosine|Inhibitor|P1 receptor|SCH 442416|SCH442416|SCH-442416

靶点活性

A2AR (rat):0.5 nM (IC50)|A2AR (human):0.048 nM (IC50)

体外活性

A2A受体拮抗剂(SCH 442416)能够提高Müller细胞中Kir 2.1和Kir 4.1通道的mRNA表达，从而在体外缺氧条件下保护视网膜神经元[1]。

溶解度

DMSO:60 mg/ml (154.08 mM)

参考文献

1.Kang X , Yu J , Wei Y , et al. The Effect of A 2A Receptor Antagonist (SCH 442416) on the mRNA Expression of Kir 2.1 and Kir 4.1 Channels in Rat Retinal Müller Cells Under Hypoxic Conditions in Vitro[J]. Advances in Clinical and Experimental Medicine, 2013, 22(6):825-829.
2.Jun Yu , Yan Yan , Yiye Chen,et al. A 2A R Antagonists Upregulate Expression of GS and GLAST in Rat Hypoxia Model.Biomed Res Int. 2020 Oct 26;2020:2054293. doi: 10.1155/2020/2054293. eCollection 2020.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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