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SC99

CAS号

882290-02-0

分子式

C15H8Cl2FN3O

主要靶点

Apoptosis|JAK|STAT

仅限科研使用

Cat No : CM04899

Print datasheet

Synonyms

ATP-binding|activation|AKT|aggregation|Apoptosis|anti-myeloma|anti-thrombotic|ERK|c-Src|Janus kinase|JAK2|JAK|inhibit|Inhibitor|myeloma|multiple|mTOR|OPM2|orally|platelet|pocket|phosphorylation|SC99|SC-99|SC 99|STAT|STAT3

验证数据展示

  • CAS No.: 882290-02-0

    SC99
    CAS#: 882290-02-0

产品信息

CAS号 882290-02-0
分子式 C15H8Cl2FN3O
主要靶点 Apoptosis|JAK|STAT
主要通路 凋亡|JAK/STAT 信号通路|血管生成|干细胞|蛋白酪氨酸激酶|表观遗传|JAK/STAT 信号通路|干细胞
分子量 336.15
纯度 99.56%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 ATP-binding|activation|AKT|aggregation|Apoptosis|anti-myeloma|anti-thrombotic|ERK|c-Src|Janus kinase|JAK2|JAK|inhibit|Inhibitor|myeloma|multiple|mTOR|OPM2|orally|platelet|pocket|phosphorylation|SC99|SC-99|SC 99|STAT|STAT3

体外活性

SC99抑制了人类血小板中JAK2和STAT3的磷酸化，但对AKT、p65或Src的磷酸化没有影响，这几种都是参与血小板激活的关键因素。SC99以剂量依赖性方式抑制由胶原蛋白和凝血酶诱导的人类血小板聚集。同时，SC99还抑制了由凝血酶引发的P-选择素表达和纤维蛋白原与单个血小板的结合。此外，SC99抑制了血小板在纤维蛋白原上的扩散和由内向外信号传导介导的血块收缩。在小鼠中，SC99抑制了血小板聚集，但并没有显著延长出血时间。作为STAT3抑制剂，SC99抑制了血小板激活和聚集。这种化合物可作为治疗血栓性疾病的有希望的化合物进行开发。

溶解度

DMSO:82 mg/mL (243.94 mM)

参考文献

1.Zhuan Xu, et at. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharmacol Sin. 2017 May;38(5):651-659.
2.Zubin Zhang, et al. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Feb 23;7(8):9296-308.

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