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SC75741

SC75741 是NF-κB 抑制剂，对p65的IC50为 200 nM。它可阻断流感病毒复制。它通过损害NF-κB 亚基 p65 的 DNA 结合，导致细胞因子，趋化因子和促凋亡因子的表达降低，抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白的核输出。

CAS号

913822-46-5

分子式

C29H23N7O2S2

主要靶点

Influenza Virus|NF-κB

仅限科研使用

Cat No : CM05274

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Synonyms

验证数据展示

  • CAS No.: 913822-46-5

    SC75741
    CAS#: 913822-46-5

产品信息

SC75741 is a potent P65 inhibitor with IC50 of 200 nM

CAS号 913822-46-5
分子式 C29H23N7O2S2
主要靶点 Influenza Virus|NF-κB
主要通路 NF-κB信号通路|微生物学
分子量 565.67
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

NF-κB:200 nM(EC50)

体内活性

SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection. [2]

体外活性

SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. [1] SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants. [2]

溶解度

H2O:<1 mg/mL,DMSO:33 mg/mL (58.3 mM),Ethanol:<1 mg/mL

细胞实验

Cell viability assay is prepared using a CellTiter-BluTM Cell Viability Assay. For each concentration of the compound four replicates are measured.(Only for Reference)

参考文献

1.Leban J, et al. Bioorg Med Chem Lett. 2007, 17(21), 5858-5862.
2.Ehrhardt C, et al. Cell Microbiol. 2013, 15(7), 1198-1211.
3.Hu, Qiuhui, Hengjun Du, Gaoxing Ma, Fei Pei, Ning Ma, Biao Yuan, Paul A. Nakata, and Wenjian Yang. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii [J]. Food Funct. 2018 Jul 17;9(7):3764-3775.

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