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SB-3CT

CAS号

292605-14-2

分子式

C15H14O3S2

主要靶点

MMP

仅限科研使用

Cat No : CM05193

Print datasheet

Synonyms

neuroprotective|permeability|MMP-9|MMP-2|MMP|metalloproteinase|Matrix metalloproteinases|matrix|Inhibitor|SB3CT|SB-3CT|SB 3CT|blood-brain|barrier|anticancer|effects|inhibit|gelatinases

验证数据展示

  • CAS No.: 292605-14-2

    SB-3CT
    CAS#: 292605-14-2

产品信息

CAS号 292605-14-2
分子式 C15H14O3S2
主要靶点 MMP
主要通路 蛋白酶体
分子量 306.4
纯度 99.38%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 neuroprotective|permeability|MMP-9|MMP-2|MMP|metalloproteinase|Matrix metalloproteinases|matrix|Inhibitor|SB3CT|SB-3CT|SB 3CT|blood-brain|barrier|anticancer|effects|inhibit|gelatinases

靶点活性

MMP2:13.9 nM(Ki)|MMP9:600 nM(Ki)

体内活性

SB-3CT能够降低溶骨性反应,有助于骨完整性的保持。在PC3肿瘤细胞中,SB-3CT抑制细胞的生长。在基底膜基质中,SB-3CT直接抑制骨髓内皮细胞浸润和小管形成。

体外活性

在栓子引起的永久性脑缺血小鼠模型中,SB-3CT通过阻碍神经元层粘连蛋白的退化,保护神经元免受缺血性细胞死亡的损害.在L-CI.5sT细胞淋巴小鼠模型中,每天腹腔注射 SB-3CT（5-50 mg/kg）,能够抑制肝癌细胞转移.在人前列腺癌细胞骨转移模型中,每天腹腔注射SB-3CT（50 mg/kg ）,抑制细胞的生长,骨质溶解以及血管生成.

溶解度

DMSO:55 mg/mL (179.5 mM);Ethanol:6.1 mg/mL (19.91 mM)

细胞实验

SB-3CT is dissolved in DMSO (10 mM) and stored (-22°C), and then diluted with appropriate media (DMSO 1%) before use[2]. PC3 cells are seeded in 35-mm dishes (5×104 cells/dish) in complete culture medium. The next day, the medium is replaced with complete medium supplemented with 1% DMSO alone (vehicle) or SB-3CT (final concentrations 0.1-50 μM) in 1% DMSO. At various times, the cells are harvested with trypsin and counted[2].

参考文献

1.Brown S, et al. J Am Chem Soc. 2000, 122 (28), 6799–6800.
2.Krüger A, et al. Cancer Res. 2005, 65(9), 3523-3526
3.Bonfil RD, et al. Int J Cancer. 2006, 118(11), 2721-2726.
4.Cui J, et al. Mol Neurodegener. 2012, 15, 7-21.
5.Lei Z, Jian M, Wei J, et al. Array-Based in situ Fluorescence Assay for Profiling Multiplex Matrix Metalloproteinases Activities in Tissue Section[J]. Analytica Chimica Acta. 2019.
6.Lei Z, Chen H, Zhang H, et al. Evaluation of Matrix Metalloproteinase Inhibition by Peptide Microarray-Based Fluorescence Assay on Polymer Brush Substrate and in Vivo Assessment[J]. ACS applied materials & interfaces. 2017 Dec 20;9(50):44241-44250.

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