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Rilpivirine

CAS号

500287-72-9

分子式

C22H18N6

主要靶点

Reverse Transcriptase|HIV Protease

仅限科研使用

Cat No : CM00735

Print datasheet

Synonyms

diarylpyrimidine|DAPY|DB08864|DB-08864|DB 08864|Human immunodeficiency virus|HIV Protease|HIVProtease|HIV|antiviral|wild-type|transcriptase|TMC278|TMC-278|TMC 278|利匹韦林|mutant|inhibit|Inhibitor|R278474|R-278474|R 278474|Rilpivirine|Reverse Transcriptase|reverse|ReverseTranscriptase|resistance|non-nucleoside|NNRTI

验证数据展示

  • CAS No.: 500287-72-9

    Rilpivirine
    CAS#: 500287-72-9

产品信息

CAS号 500287-72-9
分子式 C22H18N6
主要靶点 Reverse Transcriptase|HIV Protease
主要通路 蛋白酶体|微生物学|微生物学
分子量 366.42
纯度 98.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 diarylpyrimidine|DAPY|DB08864|DB-08864|DB 08864|Human immunodeficiency virus|HIV Protease|HIVProtease|HIV|antiviral|wild-type|transcriptase|TMC278|TMC-278|TMC 278|利匹韦林|mutant|inhibit|Inhibitor|R278474|R-278474|R 278474|Rilpivirine|Reverse Transcriptase|reverse|ReverseTranscriptase|resistance|non-nucleoside|NNRTI

体内活性

在野生型和选择性定点单一和双重HIV-1突变体中（EC50=0.1-2 nM）,Rilpivirine具有抗病毒活性。

体外活性

溶解在PEG 400中的Rilpivirine,静脉注射在大鼠中( 4 mg/kg),在犬中（1.25 mg/kg）,半衰期分别为4.4小时和31小时.

溶解度

DMSO:55 mg/mL (150.1 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Janssen PA, et al. J Med Chem. 2005, 48(6), 1901-1909.
2.Azijn H, et al. Antimicrob Agents Chemother. 2010, 54(2), 718-727.
3.Fical L. Vyvoj UHPLC-MS/MS metody pro analyzu vybranych antivirotik v HILIC a RP módu[J]. 2020
4.Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating na?ve Bayesian classification, molecular docking and drug screening approaches[J]. RSC Advances. 2018 Jan 8(10): 5286-5297.
5.Fical L, Khalikova M, Ko?ová Vl?ková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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