Resazurin sodium

CAS号

62758-13-8

分子式

C12H6NNaO4

主要靶点

Antibacterial

仅限科研使用

Cat No : CM01414

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Synonyms

Bacterial|Diazoresorcinol (sodium)|Resazurin sodium|Resazurin sodium salt|刃天青钠



产品信息

CAS号 62758-13-8
分子式 C12H6NNaO4
主要靶点 Antibacterial
主要通路 微生物学
分子量 251.17
纯度 99.14%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Bacterial|Diazoresorcinol (sodium)|Resazurin sodium|Resazurin sodium salt|刃天青钠

体内活性

在体内,resazurin 并未限制小鼠在阴道感染后与 N. gonorrhoeae 的定植。resazurin 在体内无效很可能是因为它与血清白蛋白的相互作用,这完全消减了其抗菌活性[1]。

体外活性

Resazurin 抑制包括对多种抗生素产生耐药性的 N. gonorrhoeae 分离株在内的广泛 N. gonorrhoeae 分离株的生长[1]。

溶解度

DMSO:150 mg/mL (597.21 mM)

细胞实验

Overnight broth cultures were used to inoculate FB containing resazurin sodium salt, resorufin sodium salt , resorufin acetate [Marker Gene Technologies, Eugene, OR; dissolved in dimethyl sulfoxide (DMSO)], resorufin butyrate or resorufin pentyl ether . In select experiments, FB was also supplemented with 3 g/dL bovine serum albumin (BSA) . Immediately following inoculation and 24 h later, cultures were serially diluted and were plated onto chocolate II agar. Plates were incubated at 37 °C in 5% CO2 and individual colonies were enumerated. The limit of detection was 100 CFU/mL[1].

参考文献

1.Schmitt D M , Connolly K L , Jerse A E , et al. Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo[J]. International Journal of Antimicrobial Agents, 2016:S0924857916301650.
2.Schmitt D M , O'Dee D M , Cowan B N , et al. The use of resazurin as a novel antimicrobial agent against Francisella tularensis[J]. Frontiers in Cellular and Infection Microbiology, 2013, 3.

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