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Remibrutinib

CAS号

1787294-07-8

分子式

C27H27F2N5O3

主要靶点

BTK

仅限科研使用

Cat No : CM03207

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Synonyms

Bruton tyrosine kinase|BTK|Btk|inhibit|Inhibitor|Remibrutinib

验证数据展示

  • CAS No.: 1787294-07-8

    Remibrutinib
    CAS#: 1787294-07-8

产品信息

CAS号 1787294-07-8
分子式 C27H27F2N5O3
主要靶点 BTK
主要通路 血管生成|蛋白酪氨酸激酶
分子量 507.53
纯度 99.5%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Bruton tyrosine kinase|BTK|Btk|inhibit|Inhibitor|Remibrutinib

靶点活性

BTK:1 nM

体外活性

Remibrutinib inhibits Btk enzymatic activity (IC50: 1 nM in a biochemical enzyme assay). Remibrutinib inhibits Btk enzymatic activity in the blood (IC50: 0.023 μM in vitro B cell activation assay), the whole blood is collected from the abdominal aorta of anesthetized adult male Lewis rats[1].

溶解度

DMSO:125 mg/mL (246.29 mM)

参考文献

1.Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1.
2.Kolkhir P, et al. New treatments for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2