Recombinant ALKBH2 protein
Cat No : 81129,81829 81129
|Expressed In||E. coli|
Recombinant ALKBH2 protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20% glycerol, 0.5 mM TCEP.
ALKBH2 (AlkB Homolog 2, Alpha-Ketoglutarate Dependent Dioxygenase) is a member of ALKBH protein family. It can repair alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. ALKBH2 can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. It can release modified bases from both DNA and RNA. The oxidative demethylation requires molecular oxygen, alpha-ketoglutarate and iron.
Recombinant ALKBH2 protein is suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling.
Full length ALKBH2 protein (accession number NP_001001655.1) was expressed in E. coli cells with an N-terminal 6xHis Tag. The molecular weight of ALKBH2 is 33.1 kDa.
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
This product is guaranteed for 6 months from date of receipt.
This product is for research use only and is not for use in diagnostic procedures.