Recombinant Rat t-Plasminogen activator/tPA protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat t-Plasminogen activator protein Ser33-Gln559 (Accession# P19637) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 25692 |
| 蛋白编号 | P19637 |
| 预测分子量 | 85.6 kDa |
| SDS-PAGE | 28-32 kDa, 36-38 kDa and 60-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Tissue‐type plasminogen activator (tPA) is a secreted serine protease of the trypsin family that catalyzes the critical step in fibrinolysis. It activates the circulating enzyme plasminogen, which can breakdown insoluble fibrin in the thrombus into soluble fibrin degradation products (FDPs). As thrombolytic agents, plasminogen activators are widely used to clear circulatory blockages caused by fibrin clots or thrombus. Recombinant tissue plasminogen activator (r‐tPA) has been approved by the US Food and Drug Administration as a clinical thrombolytic drug.
参考文献:
1. Collen D. et al. (1991). Blood. 78:3114‐3124. 2. Henderson SJ. et al. (2018). J Thromb Haemost. 16:1932‐1940. 3. Prabhakaran S. et al. (2015). JAMA. 313:1451‐1462.
