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Recombinant Rat TIMP-1 protein (rFc Tag)

种属

Rat

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3212

Print datasheet

Synonyms

Metalloproteinase inhibitor 1, TIMP-1, Tissue inhibitor of metalloproteinases 1

验证数据展示

  • Purity of Recombinant Rat TIMP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat TIMP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Rat TIMP-1 protein Cys24-Ala217 (Accession# P30120) with a rabbit IgG Fc tag at the C-terminus.
基因ID 116510
蛋白编号 P30120
预测分子量 47.8 kDa
SDS-PAGE 50-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Tissue Inhibitor of Metalloproteases 1 (TIMP1) is named for its well established function of inhibiting the proteolytic activity of matrix metalloproteases (MMPs). The balance between the activities of MMPs and TIMPs is essential for extracellular matrix maintenance, remodeling, and turnover in physiological events. TIMP1 inhibits extracellular matrix (ECM) degradation mediated by MMPs. TIMP1 plays a crucial role in remodeling the ECM associated with ovulation, luteinization, and degeneration. TIMP1 has several MMP-independent functions such as promotion of cell proliferation and inhibition of apoptosis. As a soluble protein secreted into the extracellular environment, TIMP1 is found in most tissues and body fluids. TIMP1 expression can be induced in several cell types, mainly due to external stimuli, such as growth factors (β-FGF, PDGF, EGF), phorbol esters, serum, and cytokines (IL-6 and IL-1).

参考文献:

1.Justo BL and Jasiulionis MG. (2021) Int J Mol Sci. 22(17):9319.
2.Schoeps B. et al. (2021) Cancer Res. 81(13):3568-3579.
3.Tan Y. et al. (2021) Biochem Pharmacol. 189:114085.
4.Hong L. et al. (2022) Arch Anim Breed. 65(1):105-111.