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Recombinant Rat NCAM-1/CD56 protein (rFc Tag)(HPLC verified)

种属

Rat

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3243

Print datasheet

Synonyms

NCAM1/CD56, CD56, Ncam, Ncam1, N-CAM-1

验证数据展示

  • Purity of Recombinant Rat NCAM-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat NCAM-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Rat NCAM-1/CD56 was greater than 90% as determined by SEC-HPLC.

    The purity of Rat NCAM-1/CD56 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Rat NCAM-1 protein Leu20-Thr721 (Accession# P13596-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 24586
蛋白编号 P13596-1
预测分子量 104.0 kDa
SDS-PAGE 120-130 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

NCAM-1 (Neural Cell Adhesion Molecule 1), also known as CD56, is a cell-surface glycoprotein that is a member of the immunoglobulin superfamily and expresses three isoforms at 120, 140, and 180 kDa. NCAM-1 plays a role in cell development and differentiation as well as in immune surveillance, and is involved in the regulation of cellular adhesion and survival, intracellular signaling, cytoskeletal dynamics, neurological development, synaptic plasticity, learning and memory, and immune surveillance. It plays a role in signal transduction by interacting with fibroblast growth factor receptor, N-calmodulin and activating the signaling cascade of FAK, MAPK, and PI3K.Abnormal NCAM-1 expression is seen in a range of hematological malignancies including multiple myeloma and leukemias, and solid tumors, such as lung cancer, ovarian cancer, and neuroblastoma.

参考文献:

1. Chu CS, et al. (2018) Psychiatry Investig.15(7):727-732.                                            
2. Sasca D, et al. (2019) Blood. 133(21):2305-2319.
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