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Recombinant Rat CXCL10/IP-10 protein (mFc Tag)

种属

Rat

纯度

>90 %, SDS-PAGE

标签

mFc Tag

生物活性

未测试

Cat no : Eg3207

Print datasheet

Synonyms

10 kDa interferon gamma-induced protein, C-X-C motif chemokine 10, Cxcl10, Gamma-IP10, Inp10

验证数据展示

  • Purity of Recombinant Rat CXCL10 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat CXCL10 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Rat CXCL10 protein Ile22-Pro98 (Accession# P48973) with a mouse IgG Fc tag at the C-terminus.
基因ID 245920
蛋白编号 P48973
预测分子量 35.3 kDa
SDS-PAGE 30 kDa and 38-40kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CXCL10, known as IP-10 (Interferon-gamma inducible Protein 10 kDa), belongs to the ELR-CXC subfamily of chemokines. CXCL10 binds to the CXCR3 receptor and triggers chemotaxis, cell growth as well as apoptosis. CXCL10 also modulates immune responses by recruiting inflammatory cells to the sites of inflammation. CXCL10 can be secreted by various types of cells, including immune cells such as T lymphocytes, neutrophils, eosinophils and monocytes. It can also be secreted by stromal cells, including thyroid cells, splenocytes, endothelial cells, fibroblasts, and keratinocytes. Interestingly, CXCL10 is not only secreted by macrophages but also activates and attracts macrophages into tissues, and thus CXCL10 substantially controls the inflammatory response as well as the tissue and matrix homeostasis.

参考文献:

1.Elemam NM, et al. (2022) Viruses. 14(11):2445.
2.Qiao X, et al. (2022) Int J Med Sci. 19(14):2058-2070.
3.Hirani DV, et al. (2023) Inflamm Regen. 43(1):52.