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验证数据展示

  • WB analysis using 22577-1-AP (same clone as 22577-1-PBS)

    WB analysis using 22577-1-AP (same clone as 22577-1-PBS)

    THP-1 cells were subjected to SDS PAGE followed by western blot with 22577-1-AP (RNASEL antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22577-1-PBS in a different storage buffer formulation.

  • WB analysis of RAW 264.7 using 22577-1-AP (same clone as 22577-1-PBS)

    WB analysis of RAW 264.7 using 22577-1-AP (same clone as 22577-1-PBS)

    RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 22577-1-AP (RNASEL Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22577-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 22577-1-AP (same clone as 22577-1-PBS)

    IHC staining of human tonsillitis using 22577-1-AP (same clone as 22577-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22577-1-AP (RNASEL Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 22577-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 22577-1-AP (same clone as 22577-1-PBS)

    IHC staining of human spleen using 22577-1-AP (same clone as 22577-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 22577-1-AP (RNASEL Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 22577-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 22577-1-AP (same clone as 22577-1-PBS)

    IF Staining of HepG2 using 22577-1-AP (same clone as 22577-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using RNASEL antibody (22577-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 22577-1-PBS in a different storage buffer formulation.

RNASEL Polyclonal antibody, PBS Only

RNASEL Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 22577-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

RNase L, RNS4, RNS 4, EC:3.1.26.-, 2-5A-dependent RNase

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

22577-1-PBS targets RNASEL in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag17409

Product name: Recombinant human RNASEL protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 392-741 aa of BC115697

Sequence: KTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAQNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEELKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
别名 RNase L, RNS4, RNS 4, EC:3.1.26.-, 2-5A-dependent RNase
计算分子量 741 aa, 84 kDa
观测分子量 84 kDa; 73 kDa
GenBank蛋白编号BC115697
基因名称 RNASEL
Gene ID (NCBI) 6041
RRIDAB_2631036
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen Affinity purified
UNIPROT IDQ05823
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RNASEL, also named as RNS4, is an endoribonuclease that functions in the interferon (IFN) antiviral response. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. There're some isoforms with calculated MW 84 kDa and 73 kDa.

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