• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

RIPK1-IN-7

CAS号

2300982-44-7

分子式

C25H22F3N5O2

主要靶点

RIP kinase

仅限科研使用

Cat No : CM15062

Print datasheet

Synonyms

TrkA|TrkB|TrkC|Receptor-interacting protein kinases|RIPK1|RIPK|RIPK1IN7|RIPK-1-IN-7|RIPK1-IN-7|RIPK1 IN 7|RIPkinase|RIP kinase|Mer|Inhibitor|Flt4|inhibit|HRI|Axl

验证数据展示

  • CAS No.: 2300982-44-7

    RIPK1-IN-7
    CAS#: 2300982-44-7

产品信息

CAS号 2300982-44-7
分子式 C25H22F3N5O2
主要靶点 RIP kinase
主要通路 凋亡|NF-κB 信号通路
分子量 481.47
纯度 98.02%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 TrkA|TrkB|TrkC|Receptor-interacting protein kinases|RIPK1|RIPK|RIPK1IN7|RIPK-1-IN-7|RIPK1-IN-7|RIPK1 IN 7|RIPkinase|RIP kinase|Mer|Inhibitor|Flt4|inhibit|HRI|Axl

靶点活性

RIPK1:(kd)4 nM |RIPK1:11 nM

体外活性

在TSZ诱导的HT29细胞坏死模型中，RIPK1-IN-7显示出强大的细胞保护效果（EC50为2nM）。RIPK1-IN-7对多个其他激酶（Flt4、TrkA、TrkB、TrkC、Axl、HRI、Mer和MAP4K5）也表现出显著活性，其IC50分别为20、26、8、7、35、26、29和27nM。

溶解度

DMSO:60 mg/mL (124.62 mM);H2O:0.1 mg/mL (insoluble)

参考文献

1.Li Y, et al. Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem. 2018 Dec 27;61(24):11398-11414.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2