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RG2833

RG2833 (RGFP109) 是一种脑渗透性 HDAC 抑制剂，对 HDAC1 和 HDAC3 的 IC50 分别为 60 nM 和 50 nM，Ki 值分别为 32 和 5 nM。

CAS号

1215493-56-3

分子式

C20H25N3O2

主要靶点

HDAC

仅限科研使用

Cat No : CM04428

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Synonyms

RGFP109

验证数据展示

  • CAS No.: 1215493-56-3

    RG2833
    CAS#: 1215493-56-3

产品信息

RG2833 (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

CAS号 1215493-56-3
分子式 C20H25N3O2
主要靶点 HDAC
主要通路 表观遗传|DNA损伤和修复
分子量 339.43
纯度 99.13%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 RGFP109

靶点活性

HDAC3:5 nM(Ki)|HDAC1:32 nM(Ki)

体外活性

In unstimulated peripheral blood mononuclear cells, RG2833 upregulates the level of the synaptic mRNA and protein in a dose-dependent manner.

溶解度

DMSO:63 mg/mL (185.6 mM),Ethanol:10 mg/mL (29.46 mM)

参考文献

1.Rai M, et al. PLoS One. 2010, 5(1), e8825.
2.Sandi C, et al. Neurobiol Dis. 2011, 42(3), 496-505.
3.Johnston TH, et al. Parkinsonism Relat Disord. 2013, 19(2), 260-264.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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