• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

RG108

RG108 (N-Phthalyl-L-tryptophan) 是一种非核苷的 DNA 甲基转移酶 (DNMTs) 抑制剂，IC50为115 nM。它阻断 DNA 甲基转移酶的活性位点，可引起抑癌基因的去甲基化和再激活。

CAS号

48208-26-0

分子式

C19H14N2O4

主要靶点

DNA Methyltransferase

仅限科研使用

Cat No : CM03699

Print datasheet

Synonyms

N-Phthalyl-L-tryptophan

验证数据展示

  • CAS No.: 48208-26-0

    RG108
    CAS#: 48208-26-0

产品信息

RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).

CAS号 48208-26-0
分子式 C19H14N2O4
主要靶点 DNA Methyltransferase
主要通路 表观遗传
分子量 334.33
纯度 99.78%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 N-Phthalyl-L-tryptophan

靶点活性

DNA methyltransferase:115 nM

体内活性

SM衍生的iPS细胞中,RG108能够明显降低DNA活性。在肿瘤细胞中,RG108抑制基因脱甲基和再活化,但是不影响着丝粒基因序列的甲基化。

溶解度

Ethanol:33.4 mg/mL (100 mM),DMSO:33.4 mg/mL (100 mM)

细胞实验

For the determination of cellular growth and viability, cells are stained with trypan blue and counted using a standard counting grid.(Only for Reference)

参考文献

1.Brueckner B, et al, Cancer Res, 2005, 65(14), 6305-6311.
2.Schirrmacher E, et al, Bioconjug Chem, 2006, 17(2), 261-266.
3.Pasha Z, et al, PLoS One, 2011, 6(8), e23667.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2